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Endogenous contrast T1rho cardiac magnetic resonance for myocardial fibrosis in hypertrophic cardiomyopathy patients.


   Background:Late gadolinium enhancement (LGE) is a standard method to evaluate myocardial fibrosis, but restricted due to contrast agent contraindications. Non-contrast T1rho can generate endogenous contrast, and detect fibrosis in chronic myocardial infarction. However, T1rho for hypertrophic cardiomyopathy (HCM) patients is still unreported. The present study aimed to investigate T1rho for fibrotic assessment and the clinical implication in HCM patients.    


Fig. 1: Wall thickening of left ventricular (LV) maximal end-diastolic wall thickness (EDTH). EDTH of LV maximal wall (arrowed line in the left panel) and end-systolic wall thickness (ESTH) of the same site (arrowed line in the right panel) were used to calculate the wall thickening. The wall thickening of LV maximal EDTH was computed by the formula: (ESTH–EDTH)/EDTH  

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