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Establishment and ultrasound characteristics of atherosclerosis in rhesus monkey.

Abstract

Background: Atherosclerosis is one of the main risk factors cause acute cerebralcardio vascular diseases. It’s of great significance to establish an atherosclerosisanimal model that can mimic the characteristics and nature course of humanpatients. Therefore, a rhesus monkey model was induced by high-fat diet to monitortheir lipid profile and intima-media thickness (IMT) of artery walls and studyatherosclerosis progression.

Conclusions: After high-fat diet induction for 96 weeks, serum lipid levels of rhesusmonkeys elevated significantly, which subsequently caused IMT thickening and plaquesformation. When IMT thickening occurred, further vascular injury may be prevented byreducing diet fat content. Our study indicates that vascular injury of high-fat dietinduced rhesus monkey is similar to that of human in position and progression.

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Fig.4. Typical ultrasound images of normal carotid arteries and aortas of different rhesus monkeys. A, B and C show images of normal intima plus medial thickness measurement of RBIF, LBIF and AO, respectively. The values of IMT in picture A, B and C are 0.3 mm, 0.4 mm and 0.3 mm respectively.


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