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Obesity
PriMed Spontaneously Non-Human Primate Model of Obesity

Non-human primates develop spontaneous obesity, metabolic syndrome, and T2DM with characteristics that are extraordinarily like those of humans. Obese, dysmetabolic, and diabetic NHPs also develop hepatic pathology with characteristics of NAFLD/NASH.
PriMed Shines rhesus colony has been studied longitudinally for 7 years under consistent dietary, procedures, and environmental conditions. This consistency is key to the characteristics of obesity, metabolic syndrome, and T2DM, and provides a quickstart for the efficacy study of obesity treatments.


PriMed Shines Spontaneously Obese NHP Capability

-- Breeding center: n=~3000 rhesus macaques (macaca mulatta)
-- Colony of n=~500 obese rhesus macaques
-- Longitudinal body weight data (monthly)
-- Dual Energy X-ray absorptiometry (DEXA) and CT for body composition


Advantages of NHPs in Preclinical Trials

-- Longitudinal long term studies -- Long enough life span for complication development (and reversal/treatment effects)
-- Highly controlled and consistent environment
-- More valid than rodents for projecting human outcomes
-- Combine pharmacokinetics, efficacy and safety
-- Discover new targets and mechanisms of action
-- Use of multiple outcome measures for validation of future clinical plan


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