Age-related hearing loss (ARHL) or presbycusis, is a complex auditory disorder that impairs spectral, temporal and spatial auditory perceptions in the aged. One of the more common deficits is a shift in the audiometric thresholds, which is most likely to be manifested peripherally due to pathological changes in the cochlea. It has been hypothesized that different patterns of ARHL emerge in the human as the result of distinct cochlear pathologies, although this dataset is necessarily limited. Subsequent studies in humans have indicated that while there are examples where a single cochlear pathology can account for changes in audiometric thresholds, there are approximately 25% of cases that result from mixed cochlear pathologies, and in most cases there are complex interactions between different elements of the cochlea.
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