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Sichuan PriMed Shines Bio-tech Co., Ltd., headquartered in Chengdu, China, is a Non-human Primate CRO with extensive research experiences of 12 years (2005-2017). PriMed Shines provides highest service to our clients in our 400,000 ft2 fully AAALAC accredited facilities.
Imaging Diagnosis
Echocardiography

PriMed has the GE Vivid S5 Ultrasound Machine on site to perform standardized echocardiography. All images were obtained by a clinical ultrasound doctor with >30 years of human ultrasound experiences and >2 years of NHPs ultrasound experiences. All data were analyzed by using GE EchoPAC software Only.



Heart Structure

LA Volume, LA Volume Index

IVSd, IVSs, LVIDd, LVIDs, LVPWd, LVPWs


Heart Function
Systolic

1, LVEF (Biplane Simpson Method)

2, EDV, ESV, SV, FS, CO

3, Longitudinal/Circumferential Strain (Speckle Tracking)

Diastolic

1, E, A, E/A, A Dur.

2, e’, a’, e’/a’, E/e’, IVRT, IVCT

3, S, D, S/D, Ar, Ar Dur., Ar-A Dur.

4, Vp


MRI

PriMed use Siemens trio 3.0T MRI machine to perform cardiac magnetic resonance by an experienced team which lead by a clinical doctor with >30 years of human MRI experiences and >4 years of NHPs MRI experiences. Data were analyzed by CVI42 Software and Matlab Software.


Function

EDV, ESV, SV, CO, LVEF


Strain

Peak systolic circumferential/longitudinal/radial strain (rate), Peak Torsion


Tissue Characteristic

ECV (cardiac fibrosis), Pre T1, Post T1, T2, T1rho, MBF


Dual-energy CT

PriMed use Siemens SOMATOM Definition Flash CT Scanner to perform abdominal Dual-energy CT on rhesus to quantify liver fat content in NAFLD/NASH monkeys. Data were analyzed by Syngo dual-energy software.

Attenuation curve, Hepatic attenuation index (△HUSn140-100kVp, HU100kVp/Sn140kVp)


Liver Ultrasound

Liver size, fatty liver, ultrasound-guided liver biopsy


Renal Ultrasound

Renal resistance index, ultrasound-guided kidney biopsy


Vessel Ultrasound

Vessel plaque, atherosclerosis


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