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Chronic Kidney Disease
PriMed Non-human Primate Model of Diabetic Kidney Disease

Diabetes is the largest cause of kidney disease in the world. In fact, approximately 10% to 20% of mortality in diabetic patients is resulted from the kidney (renal) failure. PriMed Shines provides a large collection of well-characterized naturally diabetic non-human primate (NHP) models. Our diabetic NHP models develop diabetic kidney disease with similar phenotypes as human patients, including hyperglycemia, glycosuria, albuminuria, and low GFR, providing the ideal animal model for investigating the mechanisms underlying human DKD, as well as for pharmaceutical discovery, development, and evaluation of novel therapeutic agents.


PriMed Spontaneous Diabetic Kidney Disease NHP Capability

Set up 100 DKD rhesus macaques database

With longitudinal (> 5 years) medical records, including echo, clinical pathology, body weight, food intake, vet treatment and dosing record.
Ultrasound-guided renal biopsy and histopathological examination.
Biomarkers: GFR, A/C, UAER, C.C.R, NGAL, Cystatin C, TIMP1, et al.
Well established non-invasive blood pressure measurement using a Dinamap Blood Pressure monitor.
Enalapril and Entresto have been validated with our DKD NHP model as a benchmark study.
5 compounds have been validated.


Imaging capability

Extensive Echo and MRI experiences with monkey kidney testing.
Equipped with advanced Echo, MRI and CVI software and Echo PAC Software onsite.
Kidney fibrosis (T1ρ).
30-year imaging expert as CSO.


Pathology and GFR measurement Capability

Ultrasound-guided renal biopsy.
Senior consultant has 30+ years of experience in pathology (ACVP from 1989).


Measurement of Glomerular Filtration Rate (GFR) in Rhesus Monkeys is well established

Bleeding at 120, 150, 180, 210, and 240 minutes after the iohexol injection.
Plasma iohexol concentration measured by HPLC.
One-compartment model is used to calculate GFR and GFR is corrected according to Brochner-Mortensen and normalized with body surface area. ohexol concentration measured by HPLC.


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