The non-human primate model, permitting both repeated bleeding and multiple imaging studies, provides new opportunities to understand the pathogenesis as well as to examine in detail both the progression of the disease and its response to new therapeutic agents.
Fully characterized RA (Collagen induced) monkey model
-- Dozens of compounds and antibodies have been validated
-- Targets validated with our RA NHP models: IL-6, IL-6R, IL-17, TNF-α, CD20,JAK.
-- Accurate diagnostic parameters.
Pathology and imaging experiences with X-ray, MRI.
Equipped with X ray, dual energy X-ray absorptiometry (DEXA), MRI.
-- 30-year imaging expert as CSO.
-- Pathologist with over 20-year experience.
Adalimumab and Methotrexate have been validated with our RA NHP models
-- X ray, MRI
-- Clinical score
-- Joint swelling
-- Inflammation biomarkers
-- PK/PD and toxicity profiling
Osteoarthritis (OA), is the most common chronic joint condition. Also known as degenerative joint disease, involves both articular cartilage and subchondral bone. The progression of the diseased joint includes articular cartilage fibrillation, fissure and partial erosion, complete loss of articular cartilage and ends with exposed bone and sclerosis of subchondral bone. Symptoms include joint pain, swelling and reduced angle and extent of motion. It can occur in any joint, but usually it affects hands, knees, hips or spine. A variety of causes – hereditary, developmental, metabolic, and mechanical – may initiate the processes leading to loss of cartilage. OA is the most common form of arthritis and the leading cause of chronic disability. It affects about 40 million people in the United States.
Postmenopausal osteoporosis is characterized by low bone mass and micro-architectural deterioration of bone tissue, leading to bone fragility and a consequent increase in risk of fracture. Osteoporosis causes 8.9 million fractures each year worldwide and imposes a considerable economic burden on health services. The incidence of vertebral and hip fractures increases exponentially with advancing age and are a major cause of morbidity and disability in aged people and, in the case of hip fractures, can lead to premature death.
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