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Immune Disease
Rheumatoid Arthritis

Non-human Primate

The non-human primate model, permitting both repeated bleeding and multiple imaging studies, provides new opportunities to understand the pathogenesis as well as to examine in detail both the progression of the disease and its response to new therapeutic agents.

PriMed Rheumatoid Arthritis (RA) NHP capability:

Fully characterized RA (Collagen induced) monkey model

-- Dozens of compounds and antibodies have been validated
-- Targets validated with our RA NHP models: IL-6, IL-6R, IL-17, TNF-α, CD20,JAK.
-- Accurate diagnostic parameters.

Pathology and imaging experiences with X-ray, MRI.

Equipped with X ray, dual energy X-ray absorptiometry (DEXA), MRI.

-- Immunohistochemistry.
-- 30-year imaging expert as CSO.
-- Pathologist with over 20-year experience.

Benchmark Study:

Adalimumab and Methotrexate have been validated with our RA NHP models

-- X ray, MRI
-- Clinical score
-- Joint swelling
-- Inflammation biomarkers
-- PK/PD and toxicity profiling