Home>SERVICES > Cardiovascular

SERVICES

Cardiovascular

Sichuan PriMed Shines Bio-tech Co., Ltd., headquartered in Chengdu, China, is a Non-human Primate CRO with extensive research experiences of 12 years (2005-2017). PriMed Shines provides highest service to our clients in our 400,000 ft2 fully AAALAC accredited facilities.
Cardiovascular
Cardiovascular Disease

Cardiovascular disease is the number one cause of death globally. Innovative new therapeutics that can modify or even reverse heart failure progression, especially diastolic dysfunction, are needed to reduce the disease burden in the general population.
However, research into the development of novel and improved treatments is complicated by a lack of preclinical CVD models. PriMed Shines provides highly translatable NHP models and key technologies for CVD to help progress your novel agents into the clinic.
Our CVD Imaging Translational Technology Platform provides heart failure, hypertension NHP models and multiple imaging techniques.


NHP Model

With longitudinal (2-5 years) medical records, including echo and MRI, blood pressure, metabolic status, renal function, clinical pathology, body weight, food intake, cardiac biomarkers, vet treatment and dosing record.


Heart failure

Diastolic Dysfunction and Preserved Left Ventricular Ejection Fraction with Aged, Hypertention, Pre-Diabetic/Diabetic Rhesus Monkeys Using Imaging and Circulating Biomarkers.
Diastolic Dysfunction and Preserved Left Ventricular Ejection Fraction with Aged, Hypertention, Pre-Diabetic/Diabetic, Chronic Kidney Disease(G3a-G3b) Rhesus Monkeys Using Imaging and Circulating Biomarkers.
Systolicc Dysfunction and Reduced Left Ventricular Ejection Fraction with Aged, Dyslipidimia and Atherosclerosis Rhesus Monkeys Using Imaging and Circulating Biomarkers.
With comorbidities: Diabetes, HTA, Age, Hypertension, Chronic kidney disease, pulmomary edema, dyslipidemia, Atherosclerosis


Spontaneous Chronic Heart Failure-Systolic Dysfunction

Spontaneous Chronic Heart Failure-Diabetic Diastolic Dysfunction

Spontaneous Diffuse Myocardial Fibrosis

Myocardial Ischemia

Atherosclerosis

Rhythm disorders

Tachycardia
Arrhythmia


Drugs/references tested

Entresto, Pioglitazone, GPR40 agonist, SGLT2 Inhibitor, Bydureon, Dulaglutide, Atorvastatin, Simvastatin, Ezetimibe, PCSK9 Inhibitor, Omega-3 fatty acid, Orlistat, Enalapril


Comparison of  Human and NHP Cardiovascular Disease


Mice Model

Transverse aortic constriction (TAC)

Ischemia/reperfusion

Permanent coronary ligature

Microembolization

Pacing

PriMed Posters and Publications

Connect