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SERVICES

Antibacterial
Primed antimicrobial activity evaluation capability

Collection of ~2000 clinical strains (~400 drug-resistant bacterium).

Established multiple in vivo/in vitro assays to evaluate novel antimicrobial compounds

Completed screening tests for ~500 compounds and preclinical research of ~80 compounds,some of which have been approved for clinical trials by CFDA


Gram-Positive Bacteria (~800 strains) Gram-Negative Bacteria (~1000 strains) Fungi (~200 strains)
Staphylococcus aureus (MRSA, MSSA)
Staphylococcus epidermis(MRSE, MSSE)
Streptococcus (PRSP, PSSP)
Enterococcus faecium (VRE)
Enterococcus faecalis (VRE)
Clostridium difficile
Escherichia coli (ESBLs,CRE)
Klebsiella pneumoniae ( ESBLs,KPC)
Moraxella catarrhalis
Haemophilus influenzae
Enterobacter cloacae
Enterobacter aerogenes
Acinetobacter baumannii (OXA23,integron type I)
Proteusbacillus vulgaris
Salmonella typhi
Pseudomonas aeruginosa (Integron type I, IMP4)
Salmonella
Candida krusei
Candida tropicalis
Candida albicans
Candida parapsilosis
Aspergillus niger

Functional Assays In Vitro
High throughput antimicrobial activity screening

--MIC,MIC50,MIC90,MICrange

--MBC,MBC50,MBC90,MBCrange

--KC,SBA

In vitro drug combination studies

--FIC

Analysis of drug resistance

In Vivo Infection Models (Rodent)

Clostridium difficile-associated diarrhea (CDAD) Hamster Model

Lung Infection Models

Thigh Infection Models

Systemic Infection Models(bacteria/fungi)

Others (Subdermal Infection Models/Renal Infection Models/Corneal Infection Models /Vaginal Infection Models/Scalded Skin Infection Models)

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