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Diabetes
Diabetes

Type 1 Diabetes

Type 2 Diabetes


PriMed Spontaneously Non-human Primate Model of Type 2 Diabetes

PriMed Shines provides the world’s largest collection of well-characterized spontaneous diabetic rhesus monkeys. NHP models of Type 2 diabetes (T2DM) display all of the characteristics of diabetic patients at different stages of the progressive disease, including obesity, and complications such as nephropathy and retinopathy. Our well-characterized models have been validated for metabolic defects including glucose intolerance, impaired insulin response, insulin resistance, impaired pancreatic insulin secretion function, reduced glucose disposition, etc.


PriMed Spontaneous T2DM NHP Capability

Breeding center: n=~3000 rhesus macaques.
Colony of n=~300 well-characterized spontaneously diabetic rhesus monkeys.
Historical clinical /metabolic data (8yrs.) by semiannual metabolic screenings.
Plasma and tissue sets cover normal to prediabetic, diabetic, and insulin dependent diabetic NHPs.
T2DM NHP management collaborated with Dr.Barbara C.Hansen


In vivo pharmacology capabilities include the evaluation of

Compound’s pharmacological properties (dose-response, efficacy, and PK)
Blood chemistry (lipid profile etc.)
Body weight/body composition
Food and liquid consumption
Fasting glucose and insulin index Glucose disposal rate (ivGTT, OGTT)
Islet function (graded glucose infusion, GGI)
Glucose disposition and insulin sensitivity (glucose and insulin clamps)
Renal function (urine volume, protein, glucose, creatinine excretion, GFR)
Continuous glucose monitoring by telemetry
Safety pharmacology: potential side effects
Biopsy/autopsy, histopathology
Heart or liver function (noninvasive sonography)


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